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- Title
Vapor-Induced Phase Transformations in Docetaxel.
- Authors
Tatini, Lakshmi; Krishna Reddy, K.; Someswara Rao, N.
- Abstract
Vapor-induced transformations of docetaxel anhydrous (form D) under ambient conditions have been studied using methanol, ethanol, and water as the solvent media. The online vapor-induced transformations were monitored by powder X-ray diffractometry. New solid forms (solvates/hydrates/anhydrous) of docetaxel anhydrous were obtained in stoichiometric ratios which were characterized completely using powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, and spectroscopic (C solid-state nuclear magnetic spectroscopy, solution H NMR, and Fourier transform infrared) techniques. The new forms namely methanol solvate (D), ethanol solvate (D), monohydrate (D), trihydrate (D), and anhydrous (D and D) were identified through structural analysis.
- Publication
AAPS PharmSciTech, 2012, Vol 13, Issue 2, p548
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-012-9774-7