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- Title
Clinical significance of Abolished PTEN expression to differentiate between malignant and hyperplastic endometrium as a diagnostic marker.
- Authors
Verma, Suraj; Maheshwari, Ujwala; Jadhav, Priyanka Nimbalkar; Sahu, Shilpi
- Abstract
Aim: Clinical significance of Abolished PTEN expression to differentiate between malignant and hyperplastic endometrium - A diagnostic marker. Material and Methods: We used immunohistochemistry (IHC) to compare changes in PTEN expression in 50 endometrial biopsies that were diagnosed as endometrial hyperplasia without atypia, endometrial hyperplasia with atypia, and endometrial carcinoma and the control used was PTEN IHC for carcinoma prostate. The study uses PTEN as a marker to distinguish hyperplastic non-atypical, atypical versus malignant endometrium in 50 endometrial biopsy and results were graded according to immunoreactivity scoring system (IRS). Results: PTEN was shown to be differentially expressed in atypical hyperplasia and EC in scores of 1+ and 0 or negative, while it was shown to be well expressed in hyperplasia without atypia in a score of 2+. Thirty of the fifty endometrial biopsy samples showed a score of 2+, seventeen showed 1+, and three showed 0 or negative. Conclusions: According to the current study PTEN expression is decreased in precancerous hyperplasia. PTEN IHC proved beneficial in screening precancerous hyperplasia lesions and diagnosing the earliest stage of endometrial carcinoma.
- Subjects
ENDOMETRIAL hyperplasia; ENDOMETRIUM; ENDOMETRIAL cancer; PRECANCEROUS conditions; HYPERPLASIA; DIAGNOSIS
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 4, p1192
- ISSN
0975-3583
- Publication type
Article