A case of symmetrical drug-related intertriginous and flexural exanthema (or SDRIFE) is described in a two year-old boy following treatment with oral ibuprofen. The erythematous, purpuric, macular, symmetrical rash appeared within a day over his neck and trunk, covering both clavicles. This was a rare reaction to ibuprofen in an unusual anatomical site. SDRIFE is more typical the gluteal, thigh or intertriginious areas, hence its more colloquial name, 'Baboon' syndrome.