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- Title
Is treatment of fatty liver effective on reducing carotid intima media thickness; a cohort study.
- Authors
Ghaffarifar, Saeideh; Khoshbaten, Manouchehr; Dordaei, Fattaneh; Nahandi, Maryam Zareh; Rashid, Reza Javad; Shahnazi, Tahereh
- Abstract
Aim: This study was intended to explore the effect of various drugs used to treat fatty liver on intimal-media thickness in patients with NAFLD. Background: Nonalcoholic fatty liver disease (NAFLD) is an indicator of a broad spectrum of pathologic disorders, which is characterized with macro vesicular steatosis in the absent of alcohol use. It has a wide range of laboratory, clinical and pathological presentations such as simple steatosis to the diseases like non-alcoholic steatohepatitis, fibrosis, and cirrhosis and hepatocellular cancer. Methods: In this cross - sectional study, as a part of a 10-year cohort study (from 2007-2017) at Tabriz University of Medical Sciences, a group of 100 patients with NAFLD were studied. They were examined by color doppler sonography of the carotid arteries to detect any carotid intima- media thickness, before and one year after treatment with various drugs. The effect of treatment on right and left carotid intima- media thickness (IMT) was examined by using SPSS. V21. Results: Over all, 36 (36%) patients were male and 64 (64%) were female. The mean age of the patients was a 43.5±10.3 year, ranging from 16 to 64. The decrease in patients' intima- media thickness in both right and left carotids was statistically significant (P<0.0001). Conclusion: Treatment of patients with nonalcoholic fatty liver has a significant role in reduction of their carotid intima -media thickness and consequently in reducing cerebrovascular events such as stroke.
- Subjects
FATTY liver; COLOR Doppler ultrasonography
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2018, Vol 11, Issue 1, p9
- ISSN
2008-2258
- Publication type
Article