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- Title
An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition.
- Authors
Nasr-Esfahani, Masoud; Montazerozohori, Morteza; Raeatikia, Razieh
- Abstract
An efficient Hantzsch synthesis of various substituted 1,4-dihydropyridines from an aldehyde, a β-dicarbonyl compound and ammonium acetate using p-toluenesulfonic acid in a solvent-free condition in the absence of any other co-catalyst is described. The process is simple and environmentally benign and the catalyst is commercially available and inexpensive. This method has the advantages of excellent yield (80-96%) and short reaction time (5-20 min.). Irradiation of a typical 1,4-dihydropyridine leads to the corresponding pyridine.
- Subjects
DIHYDROPYRIDINE; PYRIDINE synthesis; HANTZSCH, Arthur Rudolf; ALDEHYDES; ORGANIC solvents
- Publication
Maejo International Journal of Science & Technology, 2014, Vol 8, Issue 1, p32
- ISSN
1905-7873
- Publication type
Article