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- Title
Distinct Features of Vascular Diseases in COVID-19.
- Authors
Ceasovschih, Alexandr; Sorodoc, Victorita; Shor, Annabelle; Haliga, Raluca Ecaterina; Roth, Lynn; Lionte, Catalina; Aursulesei, Viviana Onofrei; Sirbu, Oana; Culis, Nicolae; Shapieva, Albina; Khokhar, Mohammed AR Tahir; Statescu, Cristian; Sascau, Radu A; Coman, Adorata Elena; Stoica, Alexandra; Grigorescu, Elena-Daniela; Banach, Maciej; Thomopoulos, Costas; Sorodoc, Laurentiu
- Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic was declared in early 2020 after several unexplained pneumonia cases were first reported in Wuhan, China, and subsequently in other parts of the world. Commonly, the disease comprises several clinical features, including high temperature, dry cough, shortness of breath, and hypoxia, associated with findings of interstitial pneumonia on chest X-ray and computer tomography. Nevertheless, severe forms of acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) are not limited to the respiratory tract but also may be extended to other systems, including the cardiovascular system. The bi-directional relationship between atherosclerosis and COVID-19 is accompanied by poor prognosis. The immune response hyperactivation due to SARS-CoV-2 infection causes an increased secretion of cytokines, endothelial dysfunction, and arterial stiffness, which promotes the development of atherosclerosis. Also, due to the COVID-19 pandemic, access to healthcare amenities was reduced, resulting in increased morbidity and mortality in patients at risk. Furthermore, as lockdown measures were largely adopted worldwide, the sedentary lifestyle and the increased consumption of processed nutrients or unhealthy food increased, and in the consequence, we might observe even 70% of overweight and obese population. Altogether, with the relatively low ratio of vaccinated people in many countries, and important health debt appeared, which is now and will be for next decade a large healthcare challenge. However, the experience gained in the COVID-19 pandemic and the new methods of patients' approaching have helped the medical system to overcome this crisis and will hopefully help in the case of new possible epidemics.
- Subjects
WUHAN (China); COVID-19; VASCULAR diseases; ARTERIAL diseases; CORONAVIRUS diseases; ENDOTHELIUM diseases; COVID-19 pandemic; CARDIOVASCULAR system
- Publication
Journal of Inflammation Research, 2023, Vol 16, p2783
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S417691