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- Title
A nonrandomized trial of vitamin D supplementation for Barrett’s esophagus.
- Authors
Cummings, Linda C.; Thota, Prashanthi N.; Willis, Joseph E.; Chen, Yanwen; Cooper, Gregory S.; Furey, Nancy; Bednarchik, Beth; Alashkar, Bronia M.; Dumot, John; Faulx, Ashley L.; Fink, Stephen P.; Kresak, Adam M.; Abusneineh, Basel; Barnholtz-Sloan, Jill; Leahy, Patrick; Veigl, Martina L.; Chak, Amitabh; Markowitz, Sanford D.
- Abstract
Background: Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett’s esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. Methods: BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks. Esophageal biopsies from normal plus metaplastic BE epithelium and blood samples were obtained before and after vitamin D supplementation. Serum 25-hydroxyvitamin D was measured to characterize vitamin D status. Esophageal gene expression was assessed using microarrays. Results: 18 study subjects were evaluated. The baseline mean serum 25-hydroxyvitamin D level was 27 ng/mL (normal ≥30 ng/mL). After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p<0.001). There were no significant changes in gene expression from esophageal squamous or Barrett’s epithelium including 15-PGDH after supplementation. Conclusion: BE subjects were vitamin D insufficient. Despite improved vitamin D status with supplementation, no significant alterations in gene expression profiles were noted. If vitamin D supplementation benefits BE, a longer duration or higher dose of supplementation may be needed.
- Subjects
ESOPHAGEAL cancer patients; APOPTOSIS; VITAMIN D deficiency; GENE expression in mammals; BIOPSY; GENETICS; VITAMIN deficiency
- Publication
PLoS ONE, 2017, Vol 12, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0184928