We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunomodulating activity of DW-116, a new quinolone antibiotic.
- Authors
Moon, Eun; Choi, Chung; Pyo, Suhkneung; Chung, Yong; Yoon, Sung; Lee, Dug
- Abstract
DW-116, {1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride}, is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(−) bacteria. DW-116 was evaluated for the immunomodulating activities, which is one of the efforts to investigate the mechanism of action related to the good in vivo antibacterial efficacy. The results of in vitro studies revealed there was no statistically significant increase in B and T lymphocyte proliferation. But the results of in vivo studies showed that the number of plaque forming cells (PFC), the amount of polyclonal antibodies and delayed-type hypersensitivity (DTH) were significantly increased after the repeat administration with 12 and 60 mg/kg of DW-116. Taken together, these results proposed that immunostimulating effect of DW-116 could be one of the action mechanisms for demonstrating in vivo antibacterial activities under these experimental conditions.
- Publication
Archives of Pharmacal Research, 1998, Vol 21, Issue 5, p610
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02975383