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- Title
Post‐treatment 18F‐fludeoxyglocuse‐positron emission tomography in human papillomavirus‐associated oropharyngeal cancer.
- Authors
Liu, Zhen Yu; Khoo, Denver; Hartel, Gunter; Punyadeera, Chamindie; Vasani, Sarju
- Abstract
Background: Human papillomavirus association has changed the landscape of treatment for oropharyngeal squamous cell carcinoma; it remains to be seen whether current post‐treatment surveillance schedules are effective. Objective: Evaluate whether post‐treatment surveillance of oropharyngeal cancer through FDG‐PET imaging is modified by human papillomavirus association. Methods: A prospective cohort analysis of retrospective data was conducted for patients undergoing treatment of oropharyngeal cancer between 2016 and 2018. This study was conducted at a single large tertiary referral center in Brisbane, Australia. Results: Two‐hundred and twenty‐four patients were recruited for the purposes of the study, 193 (86%) with HPV‐associated disease. In this cohort FDG‐PET had a sensitivity of 48.3%, specificity of 72.6%, positive predictive value of 23.7%, and negative predictive value of 88.8% in detecting disease recurrence. Conclusions: FDG‐PET in HPV‐associated oropharyngeal cancer has significantly lower positive predictive value when compared to non‐HPV‐associated oropharyngeal cancer. Caution should be used when interpreting positive post‐treatment FDG‐PET.
- Subjects
BRISBANE (Qld.); OROPHARYNGEAL cancer; HUMAN papillomavirus; TOMOGRAPHY; SQUAMOUS cell carcinoma; HEAD &; neck cancer
- Publication
Head & Neck, 2023, Vol 45, Issue 8, p2000
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27426