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- Title
Up‐front neck dissection followed by chemoradiotherapy for T1–T3 hypopharyngeal cancer with advanced nodal involvement.
- Authors
Sato, Mitsuo P.; Otsuki, Naoki; Kitano, Mutsukazu; Ishikawa, Kazuki; Tanaka, Kaoru; Kimura, Takayuki; Doi, Katsumi
- Abstract
Background: The advantage of up‐front neck dissection (UFND) followed by chemoradiotherapy (CRT) for hypopharyngeal cancer (HPC) with advanced neck involvement remains controversial. We aimed to determine the indications. Methods: The data of 41 and 14 patients with stage IVA/B (T1–T3 and ≥N2a) HPC who underwent UFND followed by CRT and received CRT, respectively, were retrospectively analyzed and compared. Results: The 5‐year overall survival (OS) and disease‐specific survival rates for the UFND and CRT groups were 61% and 52% (p = 0.1019), and 89% and 74% (p = 0.2333), respectively. Moreover, patients aged ≥70 years or those with a pulmonary disease history had a significantly poorer prognosis due to aspiration pneumonia in the UFND group. The 5‐year regional control (RC) for the UFND and CRT groups were 92% and 57%, respectively (p = 0.0001). Conclusions: UFND followed by CRT was feasible with satisfactory RC. To further improve OS, aspiration pneumonia prevention is essential.
- Subjects
HYPOPHARYNGEAL cancer; NECK dissection; SURVIVAL rate; CHEMORADIOTHERAPY; OVERALL survival; ASPIRATION pneumonia
- Publication
Head & Neck, 2021, Vol 43, Issue 12, p3810
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26881