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- Title
Initial clinical experience with helical tomotherapy for head and neck cancer.
- Authors
Chen, Allen M.; Jennelle, Richard L. S.; Sreeraman, Radhika; Yang, Claus C.; Tianxiao Liu; Vijayakumar, Srinivasan; Purdy, James A.
- Abstract
Background. To report a single-institutional experience with the use of helical tomotherapy (HT)-based intensity-modulated radiotherapy (IMRT) for head and neck cancer. Methods. Seventy-seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image-guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%). Results. The 2-year estimates of overall survival, local-regional control, and disease-free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local-regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high-dose planning target volume (PTV). Conclusions. HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
- Subjects
CANCER patients; HEAD &; neck cancer; DRUG therapy; SQUAMOUS cell carcinoma; CANCER treatment
- Publication
Head & Neck, 2009, Vol 31, Issue 12, p1571
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21123