We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia.
- Authors
Raymond-Speden, Emma; Tripp, Gail; Lawrence, Ben; Holdaway, David; Raymond-Speden, E; Tripp, G; Lawrence, B; Holdaway, D
- Abstract
<bold>Objective: </bold>To assess the effects of treatment for acute lymphoblastic leukemia (ALL) on children's cognitive functioning.<bold>Method: </bold>Participants were long-term survivors of ALL treated with cranial irradiation and central nervous system (CNS) chemotherapy (n = 20), or CNS chemotherapy only (n = 21), healthy children (n = 21), and children with chronic asthma (n = 21). The groups were compared on measures of intellectual, neuropsychological, and academic functioning.<bold>Results: </bold>CNS chemotherapy, with and without cranial irradiation, was associated with significantly lower levels of intellectual and academic functioning. Children with chronic asthma obtained lower scores than healthy controls, but these differences were not significant. Tests of neuropsychological functioning did not consistently separate the groups.<bold>Conclusions: </bold>CNS chemotherapy and, to a lesser extent, chronic illness both contribute to the poorer performance of long-term survivors of ALL on measures of intellectual and academic functioning.
- Subjects
LYMPHOBLASTIC leukemia in children; COGNITION in children; COGNITIVE testing; IRRADIATION; DRUG therapy; ASTHMATICS; LEUKEMIA treatment; THERAPEUTICS; ASTHMA diagnosis; COGNITION disorders diagnosis; ANTINEOPLASTIC agents; ASTHMA; BRAIN; CHRONIC diseases; COGNITION disorders; COMBINED modality therapy; COMPARATIVE studies; SPINAL injections; INTELLECT; INTELLIGENCE tests; LONG-term health care; LONGITUDINAL method; LYMPHOBLASTIC leukemia; NEUROPSYCHOLOGICAL tests; RESEARCH methodology; MEDICAL cooperation; METHOTREXATE; RESEARCH; ACHIEVEMENT; EVALUATION research; SEVERITY of illness index; DISEASE complications
- Publication
Journal of Pediatric Psychology, 2000, Vol 25, Issue 2, p59
- ISSN
0146-8693
- Publication type
journal article
- DOI
10.1093/jpepsy/25.2.59