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- Title
Urinary kallikrein excretion in chronic pancreatic diseases.
- Authors
Fabris, Carlo; Panozzo, Maria Piera; Basso, Daniela; Favero, Giuseppe Del; Plebani, Mario; Zaninotto, Martina; Fogar, Paola; Meggiato, Tamara; Scalon, Paola; Ferrara, Chiara; Naccarato, Remo; Fabris, C; Panozzo, M P; Basso, D; Del Favero, G; Plebani, M; Zaninotto, M; Fogar, P; Meggiato, T; Scalon, P
- Abstract
Variations in urinary kallikrein in pancreatic diseases were ascertained, and possible influencing factors were investigated. Serum amylase and urinary excretion of glandular kallikrein, pancreatic ribonuclease (RNase), gamma-glutamyltransferase (GGT) and amylase were measured in 24 control subjects, 39 patients with pancreatic cancer, 49 with pancreatitis and 63 with extra-pancreatic diseases. Urinary kallikrein was found to be elevated in a substantial number of patients with pancreatitis. Higher levels were detected in patients with a relapse, which was diagnosed using clinical and biochemical examinations. RNase was also increased in a high number of patients with pancreatic diseases, but was not correlated with pancreatic damage. In patients with pancreatitis, a correlation was found between urinary kallikrein and RNase excretions. No correlations were found between kallikrein and serum or urinary amylase and GGT. We can conclude that urinary kallikrein excretion increases in pancreatitis, especially when a phlogistic involvement of the pancreas is present; this condition may lead to a release of this ultrafiltrable enzyme in the circulation. Renal tubular damage, which determines a reduced reabsorption of this enzyme, seems to play a concomitant but minor role in this process.
- Subjects
AMYLASES; BLOOD coagulation factors; CHRONIC diseases; COMPARATIVE studies; ESTERASES; GASTROINTESTINAL diseases; RESEARCH methodology; MEDICAL cooperation; PANCREATIC tumors; PANCREATITIS; RESEARCH; EVALUATION research; GAMMA-glutamyltransferase
- Publication
American Journal of Nephrology, 1991, Vol 11, Issue 5, p386
- ISSN
0250-8095
- Publication type
journal article
- DOI
10.1159/000168343