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Use of spectroscopic process analytical technology for rapid quality evaluation during preparation of CHO cell culture media.
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- Biotechnology Progress, 2024, v. 40, n. 5, p. 1, doi. 10.1002/btpr.3477
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- Article
Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines.
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- Engineering in Life Sciences, 2020, v. 20, n. 3/4, p. 112, doi. 10.1002/elsc.201900124
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- Article
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity.
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- Metabolites (2218-1989), 2021, v. 11, n. 12, p. 823, doi. 10.3390/metabo11120823
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Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale-up to a 5000-liter CHO bioprocess.
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- Biotechnology Journal, 2016, v. 11, n. 9, p. 1190, doi. 10.1002/biot.201600030
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- Article
Fed‐batch performance profiles for mAb production using different intensified N − 1 seed strategies are CHO cell‐line dependent.
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- Biotechnology Progress, 2024, v. 40, n. 4, p. 1, doi. 10.1002/btpr.3446
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- Article
Antibody charge variant modulation by in vitro enzymatic treatment in different Chinese hamster ovary cell cultures.
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- Biotechnology Progress, 2022, v. 38, n. 5, p. 1, doi. 10.1002/btpr.3268
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- Article
Osmolality as a lever to modulate the N‐glycolylneuraminicacid (Neu5Gc) level of a recombinant glycoprotein produced in Chinese hamster ovary cells.
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- Biotechnology Progress, 2020, v. 36, n. 6, p. 1, doi. 10.1002/btpr.3038
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Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells.
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- Biotechnology Progress, 2020, v. 36, n. 3, p. 1, doi. 10.1002/btpr.2959
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A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures.
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- Biotechnology Progress, 2012, v. 28, n. 2, p. 490, doi. 10.1002/btpr.747
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- Article
Recent advances in upstream process development for production of recombinant adeno‐associated virus.
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- Biotechnology & Bioengineering, 2024, v. 121, n. 1, p. 53, doi. 10.1002/bit.28545
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Online monitoring and control of upstream cell culture process using 1D and 2D‐LC with SegFlow interface.
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- Biotechnology & Bioengineering, 2021, v. 118, n. 9, p. 3593, doi. 10.1002/bit.27873
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- Article
Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step.
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- Biotechnology & Bioengineering, 2021, v. 118, n. 9, p. 3334, doi. 10.1002/bit.27723
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- Article
A CFD model for predicting protein aggregation in low‐pH virial inactivation for mAb production.
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- Biotechnology & Bioengineering, 2020, v. 117, n. 11, p. 3400, doi. 10.1002/bit.27505
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Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review.
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- Biotechnology & Bioengineering, 2020, v. 117, n. 10, p. 3182, doi. 10.1002/bit.27461
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Early identification of unusually clustered mutations and root causes in therapeutic antibody development.
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- Biotechnology & Bioengineering, 2018, v. 115, n. 9, p. 2377, doi. 10.1002/bit.26728
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- Article
Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles.
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- Biotechnology & Bioengineering, 2018, v. 115, n. 7, p. 1646, doi. 10.1002/bit.26587
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- Article
Hypoxia and transforming growth factor‐beta1 pathway activation promote Chinese Hamster Ovary cell aggregation.
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- Biotechnology & Bioengineering, 2018, v. 115, n. 4, p. 1051, doi. 10.1002/bit.26520
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- Article
Vitamin B<sub>12</sub> association with mAbs: Mechanism and potential mitigation strategies.
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- Biotechnology & Bioengineering, 2018, v. 115, n. 4, p. 900, doi. 10.1002/bit.26511
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- Article
Ultrafiltration behavior of monoclonal antibodies and Fc-fusion proteins: Effects of physical properties.
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- Biotechnology & Bioengineering, 2017, v. 114, n. 9, p. 2057, doi. 10.1002/bit.26326
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A carbon dioxide stripping model for mammalian cell culture in manufacturing scale bioreactors.
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- Biotechnology & Bioengineering, 2017, v. 114, n. 6, p. 1184, doi. 10.1002/bit.26232
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Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.
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- Biotechnology & Bioengineering, 2016, v. 113, n. 4, p. 698, doi. 10.1002/bit.25810
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The use of 'Omics technology to rationally improve industrial mammalian cell line performance.
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- Biotechnology & Bioengineering, 2016, v. 113, n. 1, p. 26, doi. 10.1002/bit.25673
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Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies.
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- Biotechnology & Bioengineering, 2015, v. 112, n. 11, p. 2292, doi. 10.1002/bit.25639
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Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe.
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- Biotechnology & Bioengineering, 2011, v. 108, n. 5, p. 1215, doi. 10.1002/bit.23023
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- Article
Effects of culture conditions on N-glycolylneuraminic acid (Neu5Gc) content of a recombinant fusion protein produced in CHO cells.
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- Biotechnology & Bioengineering, 2010, v. 105, n. 6, p. 1048, doi. 10.1002/bit.22644
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- Article
Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner.
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- Biotechnology & Bioengineering, 1994, v. 43, n. 6, p. 505, doi. 10.1002/bit.260430611
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- Article
Metabolic understanding of disulfide reduction during monoclonal antibody production.
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- Applied Microbiology & Biotechnology, 2020, v. 104, n. 22, p. 9655, doi. 10.1007/s00253-020-10916-1
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- Article
Identification of Cell Culture Factors Influencing Afucosylation Levels in Monoclonal Antibodies by Partial Least-Squares Regression and Variable Importance Metrics.
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- Processes, 2023, v. 11, n. 1, p. 223, doi. 10.3390/pr11010223
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- Article
Insights into the Impact of Rosmarinic Acid on CHO Cell Culture Improvement through Transcriptomics Analysis.
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- Processes, 2022, v. 10, n. 3, p. 533, doi. 10.3390/pr10030533
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- Article
Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning.
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- Bioengineering (Basel), 2022, v. 9, n. 4, p. 173, doi. 10.3390/bioengineering9040173
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- Article
N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing.
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- Bioengineering (Basel), 2022, v. 9, n. 4, p. 128, doi. 10.3390/bioengineering9040128
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- Article
Impact of preparation pH and temperature on amino acid stability of highly concentrated cell culture feed media.
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- Journal of Chemical Technology & Biotechnology, 2022, v. 97, n. 8, p. 2078, doi. 10.1002/jctb.7078
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- Article
Cell Aggregation in a Chinese Hamster Ovary Cell Microcarrier Culture Affects the Expression Rate and N-linked Glycosylation of Recombinant Mouse Placental Lactogen-1<sup>a</sup>.
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- Annals of the New York Academy of Sciences, 1994, v. 745, n. 1, p. 360, doi. 10.1111/j.1749-6632.1994.tb44388.x
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An innovative hybrid modeling approach for simultaneous prediction of cell culture process dynamics and product quality.
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- Biotechnology Journal, 2024, v. 19, n. 3, p. 1, doi. 10.1002/biot.202300473
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- Article
Strategies for controlling afucosylation in monoclonal antibodies during upstream manufacturing.
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- Biotechnology Journal, 2023, v. 18, n. 7, p. 1, doi. 10.1002/biot.202200604
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- Article
Influence of the Measurement Volume on the Phase Error in Phase Doppler Anemometry.
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- Particle & Particle Systems Characterization, 1996, v. 13, n. 1, p. 18, doi. 10.1002/ppsc.19960130105
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Influence of the Measurement Volume on the Phase Error in Phase Doppler Anemometry. Part 1: Reflective mode operation.
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- Particle & Particle Systems Characterization, 1994, v. 11, n. 4, p. 339, doi. 10.1002/ppsc.19940110410
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Generalized Theory for the Simultaneous Measurement of Particle Size and Velocity using laser doppler and laser two-focus methods.
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- Particle & Particle Systems Characterization, 1993, v. 10, n. 3, p. 138, doi. 10.1002/ppsc.19930100306
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- Article
NMR-based metabolomics of mammalian cell and tissue cultures.
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- Journal of Biomolecular NMR, 2011, v. 49, n. 3/4, p. 195, doi. 10.1007/s10858-011-9490-8
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- Article
Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process.
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- Bioresources & Bioprocessing, 2020, v. 7, n. 1, p. 1, doi. 10.1186/s40643-020-00318-6
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- Article
Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing.
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- Bioresources & Bioprocessing, 2020, v. 7, n. 1, p. 1, doi. 10.1186/s40643-020-00304-y
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- Article
Investigation of a cleaning procedure for silicon spheres used in the realization and dissemination of the redefined kilogram via combined spectroscopic and gravimetric measurements.
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- International Journal of Metrology & Quality Engineering, 2021, v. 12, p. 1, doi. 10.1051/ijmqe/2020016
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- Article
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process.
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- PLoS ONE, 2016, v. 11, n. 6, p. 1, doi. 10.1371/journal.pone.0157111
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- Article