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- Title
Iron Induces Proliferation and Morphogenesis in Primmorphs from the Marine Sponge Suberites domuncula.
- Authors
Krasko, Anatoli; Schröder, Heinz C.; Batel, Renato; Grebenjuk, Vladislav A.; Steffen, Renate; Müller, Isabel M.; Müller, Werner E.G.
- Abstract
Dissociated cells from marine demosponges retain their proliferation capacity if they are allowed to form special aggregates, the primmorphs. On the basis of incorporation studies and septin gene expression, we show that Fe[sup 3+] ions are required for the proliferation of cells in primmorphs from Suberites domuncula. In parallel, Fe[sup 3+] induced the expression of ferritin and strongly stimulated the synthesis of spicules. This result is supported by the finding that the enzymatic activity of silicatein, converting organosilicon to silicic acid, depends on Fe[sup 3+]. Moreover, the expression of a scavenger receptor molecule, possibly involved in the morphology of spicules, depends on the presence of Fe[sup 3+]. We conclude that iron is an essential factor in proliferative and morphogenetic processes in primmorphs.
- Subjects
CELL proliferation; PHYSIOLOGICAL effects of iron
- Publication
DNA & Cell Biology, 2002, Vol 21, Issue 1, p67
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/10445490252810320