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- Title
Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44.
- Authors
Pinheiro, Céline; Reis, Rui M.; Ricardo, Sara; Longatto-Filho, Adhemar; Schmitt, Fernando; Baltazar, Fátima
- Abstract
Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value ofMCT expression in cancer is still poorly understood. In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44. MCT expression frequency was high and heterogeneous among the different tumours. Comparing with normal tissues, there was an increase inMCT1 and MCT4 expressions in breast carcinoma and a decrease inMCT4 plasma membrane expression in lung cancer. There were associations between CD147 andMCT1 expressions in ovarian cancer as well as between CD147 and MCT4 in both breast and lung cancers. CD44 was only associated with MCT1 plasma membrane expression in lung cancer. An important number of MCT1 positive cases are negative for both chaperones, suggesting that MCT plasma membrane expression in tumours may depend on a yet nonidentified regulatory protein.
- Subjects
CANCER cell growth regulation; BREAST cancer; COLON cancer; CELL membranes; OVARIAN cancer; MOLECULAR chaperones; ONCOLOGY
- Publication
Journal of Biomedicine & Biotechnology, 2010, p1
- ISSN
1110-7243
- Publication type
Article
- DOI
10.1155/2010/427694