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- Title
Antibodies Raised Against Bovine β-Lactoglobulin React with β<sub>2</sub>-Microglobulin.
- Authors
CONTI, Amedeo; GODOVAC-ZIMMERMANN, Jasminka
- Abstract
β-Lactoglobulin is a major whey protein in bovine milk. Its presence has been demonstrated in all mammals examined except rodents and humans. However a positive cross reaction was observed for human milk proteins with antibodies raised against bovine β-lactoglobulin. We isolated and characterized a protein fraction of ca. 12 kDa responsible for the positive cross reaction. N-terminal sequencing and amino-acid analysis indicated that this protein is identical with human β2-microglobulin. We observed structural homology between β-lactoglobulin region 124-140 and β2-microglobulin 71-86, which suggested that positions 124-140 could be the antigenic region for β-lactoglobulin. Six highly conserved amino-acid residues are suggested as candidates for the antigenic site.
- Publication
Biological Chemistry, 1990, Vol 371, Issue 1, p261
- ISSN
1431-6730
- Publication type
Article