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- Title
Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images in a rat model with regional liver irradiation.
- Authors
Furuta, Toshihiro; Yamaguchi, Masayuki; Nakagami, Ryutaro; Akahane, Masaaki; Minami, Manabu; Ohtomo, Kuni; Fujii, Hirofumi
- Abstract
Object: To determine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging could demonstrate signal recovery delay in irradiated areas of rat livers. We also investigated the relationship between MR imaging and histological findings. Materials and methods: Twelve rats received 20 μmol iron/kg of SPIO followed by X-irradiation to the right upper abdomen 4 h later. Radiation doses were 0, 50 and 70 Gy. Hepatic signals were assessed on unenhanced T-weighted images for up to 7 days using a 9.4-Tesla scanner. The livers were excised on day 7 and examined histologically. Results: Normalized relative signal intensity of 70 Gy-irradiated right liver lobe (2.36 ± 0.22) and 50 Gy-irradiated right liver lobe (2.37 ± 0.46) was significantly lower than that of the non-irradiated right liver lobe (4.04 ± 0.28) on day 7, respectively ( p < 0.05). Pearson product-moment correlation coefficient between relative intensity of the liver and the number of hepatic iron deposits was −0.588 ( p < 0.01). Conclusion: Superparamagnetic iron oxide-enhanced MR imaging could demonstrate signal recovery delay in irradiated areas of rat livers. It seems that the signal recovery delay in irradiated areas was due to SPIO-derived iron deposition. Hepatic signal recovery could be a novel diagnostic marker for delineation of irradiated areas.
- Subjects
LIVER cancer; LABORATORY rats; KUPFFER cells; RADIOTHERAPY; IRON oxides; DOSIMETERS; MAGNETIC resonance imaging
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2014, Vol 27, Issue 6, p501
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-014-0434-7