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- Title
Electrophysiological findings in extensive macular atrophy with pseudodrusen.
- Authors
Watanabe, Sung Eun Song; Quercia, Andressa Zanini Fantato; Sacai, Paula Yuri
- Abstract
Purpose: To present electroretinogram findings in extensive macular atrophy with pseudodrusen (EMAP) and describe associated systemic factors. Design: Retrospective case series. Methods: Data on medical history, visual symptoms, multimodal imaging findings, and visual field were collected from the medical records of patients with extensive macular atrophy with pseudodrusen who attended a visual electrophysiology laboratory. Electrophysiological tests, including full-field electroretinogram, multifocal electroretinogram and photopic negative response, were performed. Results: Eighteen patients (10 [56%] females, age 49–66 years) were included. Of these, 17 (94%) had a history of rheumatic fever in childhood and/or adolescence, 7 (39%) had cardiovascular disease, 4 (22%) had autoimmune disease, and 10 (56%) had inflammatory conditions. The primary visual complaints were nyctalopia (95%), followed by visual field loss (67%) and dyschromatopsia (67%). The key retinal findings included retinal pigmented epithelium atrophy in the macular region and subretinal drusenoid deposits. Regarding electrophysiological results, 100% of patients had abnormalities on multifocal electroretinogram, 94% displayed alterations in photopic negative response, and 78% showed changes in the full-field electroretinogram. Conclusions: In this cohort, electrophysiologic evaluation demonstrated diffuse retinal dysfunction affecting all layers of the retina in patients with EMAP. The disease is associated with immune-mediated systemic conditions, chiefly rheumatic fever.
- Subjects
ELECTROPHYSIOLOGY; ATROPHY; RHEUMATIC fever; ELECTRORETINOGRAPHY; VISUAL fields; MEDICAL records
- Publication
Documenta Ophthalmologica, 2023, Vol 147, Issue 2, p121
- ISSN
0012-4486
- Publication type
Article
- DOI
10.1007/s10633-023-09941-y