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- Title
Do mechanosensitive Piezo channels set in motion cell volume regulation?
- Authors
Mongin, Alexander A.
- Abstract
This document is a commentary on the emerging literature linking the mechanosensitive ion channel Piezo1 to cell volume homeostasis. The authors discuss the connection between mechanotransduction and cell volume control, highlighting the complex structure of Piezo1 and its activation by membrane indentation, negative suction, and hypoosmotic swelling. Cell volume regulation is essential for maintaining intracellular water content, preserving ionic gradients, and protecting cellular architecture. The authors present evidence suggesting that Piezo1 plays a role in cell volume control, particularly in red blood cells and osmotically swollen HEK293 cells, but acknowledge the need for further research to fully understand its importance.
- Subjects
CELL size; CELLULAR control mechanisms; ION channels; MECHANOTRANSDUCTION (Cytology); HEMATOCRIT; MOLECULAR biology
- Publication
Pflügers Archiv: European Journal of Physiology, 2024, Vol 476, Issue 7, p1019
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-024-02973-6