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- Title
An Efficient Stereoselective Synthesis of Key Fragments of Elaiophylin.
- Authors
Padmaja, Pannala; Reddy, Pedavenkatagari Narayana; Yadav, Jhillu Singh
- Abstract
The stereoselective synthesis of key fragments 3 and 7 of elaiophylin has been accomplished from readily available epichlorohydrin as the starting material. The key reactions involved are Jacobsen's kinetic resolution, Prins cyclization, pyridinium chlorochromate-mediated oxidative cleavage, Grignard reaction, and cross-metathesis reaction.
- Subjects
MACROLIDE antibiotics synthesis; STEREOSELECTIVE reactions; EPICHLOROHYDRIN; CHEMICAL kinetics; RING formation (Chemistry); METATHESIS reactions
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 7, p506
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201600006