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- Title
Two New Flavanols from Glycosmis pentaphylla and Their Cytotoxic Activities.
- Authors
Wang, Jiangfeng; Zhao, Bing; Zhang, Feng; Zhang, Qiongyu
- Abstract
Two new flavanols, (8 S,9 R)-9,10-dihydro-5,9-dihydroxy-8-(3,4,5-trimethoxyphenyl)-2 H,8 H-benzo[1,2- b:3,4- b′]dipyran-2-one ( 1) and (2 S,3 R)-3,4-dihydro-3,5-dihydroxy-2-(3,4,5-trimethoxyphenyl)-2 H,8 H-benzo[1,2- b:3,4- b′]dipyran-8-one ( 2), were isolated from the stems of Glycosmis pentaphylla. The structures of these compounds were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D- and 2D-NMR) analyses. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that compounds 1 and 2 exhibited considerable cytotoxic activities against HL-60 and A549 cell lines.
- Subjects
GLYCOSMIS pentaphylla; FLAVANOLS; FLAVONOIDS; GLYCOSMIS; RUTACEAE
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 1, p30
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201400362