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- Title
Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis.
- Authors
Fu, Ka-Li; Shen, Yun-Heng; Lu, Lu; Li, Bo; He, Yi-Ren; Yang, Xian-Wen; Su, Juan; Liu, Run-Hui; Zhang, Wei-Dong
- Abstract
Two unusual rearranged flavan derivatives with a rare bicyclo[3.3.1]non-3-ene-2,9-dione ring, tazettone A ( 1) and tazettone B ( 2), together with five known flavans, 3- 7, were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. The structures of two new compounds were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopy. All of the isolated compounds were evaluated for their cytotoxicities against four human tumor cell lines A549, HCT116, SK-BR-3, and HepG2. Compounds 1 and 2 were almost inactive against all tested cell lines, while compounds 3- 7 exhibited moderate or weak cytotoxicities against the tested cell lines.
- Subjects
FLAVANS; AMARYLLIDACEAE; NUCLEAR magnetic resonance spectroscopy; TUMORS; CELL lines
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 2, p338
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200248