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- Title
Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome.
- Authors
Alnaggar, Mohammed; Mao Lin; Mesmar, Adnan; Shuzhen Liang; Qaid, Ammar; Kecheng Xu; Jibing Chen; Lizhi Niu; Zhinan Yin
- Abstract
Background/Aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC). Methods: The study involved 40 patients with stage IV HCC who were divided equally into two groups: 1) simple IRE; and 2) IRE plus allogenic NK cells (IRE-NK); we mainly assessed the overall survival (OS). Results: The effect of the IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, it also decreased alpha-fetoprotein expression and showed significantly good clinical effectiveness. At the median 7.6-month follow-up (range, 3.8-12.1 months), median OS was higher in the IRENK group (10.1 months) than in the IRE group (8.9 months, P = 0.0078). Conclusion: IRE combined with allogeneic NK cell immunotherapy significantly increases the median OS of patients with stage IV HCC.
- Subjects
KILLER cells; IMMUNOCOMPETENT cells; LIVER cancer; IMMUNOTHERAPY; ELECTROPORATION
- Publication
Cellular Physiology & Biochemistry (Karger AG), 2018, Vol 48, Issue 5, p1882
- ISSN
1015-8987
- Publication type
Article
- DOI
10.1159/000492509