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- Title
Synthesis and Anticonvulsive Activity of 7-Amino-Substituted Cyclopenta[4′,5′]-pyrido[3′,2′:4,5]furo[3,2- d]pyrimidines.
- Authors
Sirakanyan, S.; Ovakimyan, A.; Noravyan, A.; Dzhagatspanyan, I.; Shakhatuni, A.; Nazaryan, I.; Akopyan, A.
- Abstract
Methods for the synthesis of new cyclopenta[4′,5′]pyrido[3′,2′:4,5]furo[3,2- d]pyrimidine derivatives based on 3-oxo-derivatives of cyclopenta[ c]pyridines were developed. O-alkylated derivatives of these latter compounds were cyclized to furo[2,3- b]pyridines, which were converted to furo[3,2- d]pyrimidin-7-ones with formamide. Subsequent chlorination and amination of 7-oxo derivatives yielded 7-amino derivatives. The anticonvulsive and predicted tranquillizer activities of the compounds synthesized here were assessed. Compounds with anticonvulsant properties were identified.
- Subjects
ANTICONVULSANTS; PYRIMIDINE synthesis; ALKYLATION; FORMAMIDE; CHLORINATION; AMINATION; RING formation (Chemistry)
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 3, p130
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0910-9