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- Title
An approach to regioselective synthesis of pyrazole and isoxazole derivatives and study of their antimicrobial effect.
- Authors
Chauhan, R.; Siddiqi, A.; Dwivedi, J.
- Abstract
The synthesis of 4,3-dihydro, 5-phenyl,4-(1 H-indolyl)-3-(3′4′5′-substituted pyrazole/oxazole) derivatives from [(3-phenyl-4,5-dihydro-5-substituted phenyl)-1 H-pyrazole/oxazole]-1 H-indolyl and [(3-phenyl-4,5-dihydro-5-substituted phenyl-1 H-pyrazole/oxazole]-1 H-(3-substituted indolyl) is described. The structures of the synthesized compounds have been established by elemental analysis and IR, H NMR, and mass spectroscopy. The synthesized compounds have been tested against reference microbial strains, and most tests showed excellent results.
- Subjects
REGIOSELECTIVITY (Chemistry); PYRAZOLE derivatives; ISOXAZOLES; ORGANIC synthesis; MOLECULAR structure; ANTI-infective agents; NUCLEAR magnetic resonance spectroscopy; ANTIFUNGAL agents
- Publication
Pharmaceutical Chemistry Journal, 2012, Vol 46, Issue 5, p316
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-012-0789-x