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- Title
VİTİLİGODA İNTERLÖKİN 18 GEN POLİMORFİZMLERİNİN ANALİZİ.
- Authors
Genç, Güneş Çakmak; Çelik, Sevim Karakaş; Solak, Nilgün; Edgünlü, Tuba; Türkcü, Ümmühani Özel; Dursun, Ahmet
- Abstract
Objective: Vitiligo is a common pigmentary disorder caused by the destruction of functional melanocytes. Its immunopathogenesis is not completely understood, but inflammatory alterations in the skin microenvironment, and particularly increased expression of the cytokines, are thought to be essential regulators of melanocyte dysfunction and death. Treatment of vitiligo using IFN-γ inhibition has given positive responses. Interleukin-18 (IL-18) is a cytokine that plays an important role in the Th1 response, by its ability to induce IFN-γ production in T cells and natural killer cells. The IL18 promoter is highly polymorphic containing several polymorphisms which have been described in the promoter region of IL18. Most of them were not reported to be associated with IL-18 production, only the -137 G/C (rs187238) and -607 C/A (rs1946518) SNPs in the promoter affect its promoter activity and IL-18 production was demonstrated. In addition, these SNPs have been reported to be associated with several autoimmune and inflammatory disorders. To our knowledge, no study has investigated the association between vitiligo and IL18 gene polymorphisms. We investigated the frequencies of the two abovementioned IL18 promoter alterations in vitiligo patients and control subjects to determine whether these variants might represent susceptibility factors for vitiligo. Method: IL18 promoter polymorphisms of 89 patients with vitiligo and 87 healthy participants were analyzed by PCR-RFLP method. Results: There were no significant differences in the genotype and allele frequency of IL18 rs187238, and rs1946518 SNPs when compared to vitiligo patients with healthy subjects. The frequency of the CC genotype of IL18 rs187238 tended to decrease in vitiligo patients compared to healthy subjects but was not statistically significant (p=0.213). In haplotype analysis of two SNPs in the IL18 gene also did not reach statistical significance (p=0.715). Conclusion: In conclusion, our results suggest that IL18 gene polymorphisms were not played a key role in the pathogenesis of vitiligo. In addition, because of the relatively small number of subjects, our findings are preliminary and need to be validated in further studies with larger sample sizes.
- Subjects
INTERLEUKINS; SINGLE nucleotide polymorphisms; KILLER cells; RISK assessment; INTERFERONS; COMPARATIVE studies; DISEASE susceptibility; GENOTYPES; DESCRIPTIVE statistics; HAPLOTYPES; POLYMERASE chain reaction; T cells; VITILIGO; CHEMICAL inhibitors; DISEASE risk factors
- Publication
Karya Journal of Health Science, 2022, Vol 3, Issue 3, p318
- ISSN
2717-9540
- Publication type
Article
- DOI
10.52831/kjhs.1180771