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- Title
Predominance of Rotavirus G1[P8] Genotype among Under-Five Children with Gastroenteritis in Mwanza, Tanzania.
- Authors
Hokororo, Adolfine; Kidenya, Benson R.; Seni, Jeremiah; Mapaseka, Seheri; Mphahlele, Jeffrey; Mshana, Stephen E.
- Abstract
We analyzed stool samples from underfives with gastroenteritis for rotavirus infection between January 2010 and June 2011. A total of 393 stool specimens were examined for rotavirus infection using enzyme-linked immunosorbent assay (ELISA). Hundred selected positive specimens were genotyped using multiplex polymerase chain reaction. Out of 393 underfives, 194 (49.4%) had rotavirus infection, with 96.9% of infected underfives being <2 years. Underfives infected with rotavirus had prolonged hospital stay than those without rotavirus infection (P = 0.0001). G1 was the most predominant G type (59%) followed by G8 (13%) while P[8] was the most predominant P type (25%). In single-type infection, common G–P combinations were G1P[8] (24%) and G1P[6] (17%). Common mixed infections were G1/G8 (16%) and P4/P8 (13%). G1 genotype is common among underfives with gastroenteritis in Mwanza. Diversity of genotypes causing gastroenteritis in Mwanza necessitates a continuous surveillance after the introduction of RotaRix® vaccine.
- Subjects
MWANZA (Tanzania); ROTAVIRUS diseases; GASTROENTERITIS in children; FECAL analysis; ENZYME-linked immunosorbent assay; POLYMERASE chain reaction; LENGTH of stay in hospitals
- Publication
Journal of Tropical Pediatrics, 2014, Vol 60, Issue 5, p393
- ISSN
0142-6338
- Publication type
Article
- DOI
10.1093/tropej/fmu028