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- Title
Deletion of a coordinate regulator of type 2 cytokine expression in mice.
- Authors
Mohrs, Markus; Blankespoor, Catherine M.; Wang, Zhi-En; Loots, Gaby G.; Afzal, Veena; Hadeiba, Husein; Shinkai, Kanade; Rubin, Edward M.; Locksley, Richard M.
- Abstract
Mechanisms that underlie the patterning of cytokine expression in T helper (TH) cell subsets remain incompletely defined. An evolutionarily conserved ∼400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop TH2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-/- mice maintained their capacity to produce interleukin 4. A T cell?specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity.
- Subjects
CYTOKINES; GENE expression; T cells
- Publication
Nature Immunology, 2001, Vol 2, Issue 9, p842
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni0901-842