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- Title
EXPLORING THE ACTIONS OF KETAMINE: ABNORMAL FAST BRAIN RHYTHMS IN FREELY MOVING RODENTS.
- Authors
HUNT, MARK JEREMY; PODOLECKA, WIKTORIA; WRÓBEL, JACEK
- Abstract
Introduction: Ketamine is a psychoactive agent that produces a psychotic-like dissociative state used to model certain features of schizophrenia. Over the last twenty years, ketamine has emerged as an important drug in the treatment of depression, with its clinical efficacy often linked to dissociation. Despite its increasing popularity, how ketamine produces its effects in the brain remains relatively poorly understood. This talk will focus on recent findings from animal models showing that ketamine produces fast brain rhythms. Aim: One way to investigate how ketamine affects brain activity is through electro-physiological recordings directly from experimental animals. Material and methods: Rats were implanted wiThelectrodes in the olfactory bulb and related brain regions and administered a subaesthetic dose of ketamine. Results: Ketamine injection was associated with the rapid generation of fast brain rhythms that can be recorded in diverse regions. The olfactory bulb is an important generator of this activity and is dependent on nasal airflow. Conclusions: We speculate that ketamine-induced fast brain rhythm reflects the abnormal firing of neurons which may contribute to the psychosis-like features produced by this drug.
- Subjects
BRAIN waves; KETAMINE; KETAMINE abuse; OLFACTORY bulb; RODENTS; LABORATORY animals
- Publication
Medical Science Pulse, 2024, Vol 18, p47
- ISSN
2544-1558
- Publication type
Article