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- Title
Genetic Variations Influencing Glucose Homeostasis and Insulin Secretion and their Associations with Autism Spectrum Disorder in Kazakhstan.
- Authors
Mukhtarova, Kymbat; Kanderzhanova, Akbota; Issanov, Alpamys; Chan, Chee Kai
- Abstract
Introduction: There is a complex interaction between glucose and insulin homeostasis pathways, diabetes and autism spectrum disorder (ASD). It is known that neuronal migration pathways may be interrupted by intrauterine hyperinsulinemia and hyperglycemia. Moreover, neonatal hypoglycemia which is related to mitochondrial dysfunction has a potential role that influences ASD pathogenesis [6,7]. We present here a preliminary case-control study on children and adolescents (8 - 15 years old) with and without autism spectrum disorder examining the association between genetic polymorphisms impacting glucose and insulin homeostasis and autism spectrum disorder in Kazakhstan. Methods: In this case-control study looking at 211 samples, associations of glucose and insulin homeostasis gene polymorphisms of 10 genes and demographic variables with autism spectrum disorder were examined. Fisher's exact test and multivariate logistic regression models were used to find associations between polymorphisms and other predictors. Results: Preliminary results suggest that there is a complex relation between autism spectrum disorder and genetic variations that are associated with impaired glucose and insulin homeostasis susceptibility. There is a significant association of the T allele of ADIPOQ (rs1501299) (OR=1.75, 95% CI:1.04-2.93, p-value=0.035); the T allele of GCKR (rs1260326) (OR=0.6, 95% CI:0.39-0.93, p-value=0.023); the T allele of SLC30A8 (rs13266634) (OR=1.77, 95% CI:1.12-2.78, p-value=0.014); and the recessive GG genotype of rs10757278 (CDKN2B) (OR=2.58, 95% CI: 1.24-5.36, p-value=0.011) with autism spectrum disorder in the Kazakhstan population. Conclusion: Overall, this preliminary study revealed that there is evidence of significant associations between glucose and insulin homeostasis gene polymorphisms and autism spectrum disorder susceptibility in Kazakhstan and further study in this area to further verify this, is needed.
- Subjects
KAZAKHSTAN; AUTISM risk factors; HOMEOSTASIS; STATISTICS; GENETICS; CONFIDENCE intervals; MULTIPLE regression analysis; AGE distribution; BLOOD sugar; CASE-control method; GENETIC polymorphisms; FISHER exact test; ALLELES; MANN Whitney U Test; INSULIN; CELLULAR signal transduction; SURVEYS; SEX distribution; DISEASE susceptibility; RESEARCH funding; GENOTYPES; DESCRIPTIVE statistics; ODDS ratio; DATA analysis software; ETHNIC groups; BODY mass index
- Publication
Electronic Journal of General Medicine, 2021, Vol 18, Issue 2, p1
- ISSN
2516-3507
- Publication type
Article
- DOI
10.29333/ejgm/9677