We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Response to Kang et al.
- Authors
Garcia-Prieto, Carlos A; Davalos, Veronica; Esteller, Manel
- Abstract
Their results align with ours, confirming that naïve T-cell subsets are overrepresented in EPICART-positive cells, supporting the emerging evidence that chimeric antigen receptor T cells exhibiting these features are associated with improved patient outcomes ([4]). Importantly, recent findings in chimeric antigen receptor T cells further demonstrate that DNA methylation impacts T-cell function and clinical efficacy according to culture time ([5]). We are glad to learn that Kang et al. ([1]) have successfully replicated our findings, confirming that a profile of DNA methylation in chimeric antigen receptor (CAR) T cells (termed EPICART signature in our case) is enriched in naïve T-cell subsets that are likely associated with improved clinical response in B-cell malignancies.
- Subjects
CHIMERIC antigen receptors; T-cell exhaustion
- Publication
JNCI: Journal of the National Cancer Institute, 2023, Vol 115, Issue 10, p1234
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djad166