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- Title
RE: NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis.
- Authors
Nonneville, Alexandre de; Finetti, Pascal; Mamessier, Emilie; Bertucci, François; de Nonneville, Alexandre
- Abstract
Through analysis of preclinical models from endocrine receptor (ER)-/HER2+ and triple-negative (TN) inflammatory breast cancers (BCs) and of clinical BC samples, Villodre et al. ([1]) suggest that NDRG1 critically contributes to tumor growth and metastasis in aggressive ER-negative BCs. A) Kaplan-Meier postoperative OS curves according to NDRG1 status in endocrine receptor (ER)+/HER2- breast cancers (BCs). Cell lines drug sensitivity data and proteomics data are publicly available and were derived from the Genomics of Drug Sensitivity in Cancer dataset ([6]) and protein array dataset from the Cancer Cell Line Encyclopedia ([7]) using the online DepMap web tool (https://depmap.org, version 21Q4).
- Subjects
CELL cycle proteins; BRAIN tumors; BREAST; BREAST tumors
- Publication
JNCI: Journal of the National Cancer Institute, 2022, Vol 114, Issue 7, p1046
- ISSN
0027-8874
- Publication type
editorial
- DOI
10.1093/jnci/djac031