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- Title
Longitudinal Study of Human Papillomavirus Persistence and Cervical Intraepithelial Neoplasia Grade 2/3: Critical Role of Duration of Infection.
- Authors
Rodríguez, Ana Cecilia; Schiffman, Mark; Herrero, Rolando; Hildesheim, Allan; Bratti, Concepción; Sherman, Mark E.; Solomon, Diane; Guillén, Diego; Alfaro, Mario; Morales, Jorge; Hutchinson, Martha; Katki, Hormuzd; Cheung, Li; Wacholder, Sholom; Burk, Robert D.
- Abstract
Background: The natural history of human papillomavirus (HPV) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. In a 7-year population-based cohort study in Guanacaste, Costa Rica, we examined whether women’s age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease.
- Subjects
GUANACASTE (Costa Rica); COSTA Rica; PAPILLOMAVIRUSES; DISEASES in older women; INFECTION; VACCINATION; MEDICAL screening; COHORT analysis
- Publication
JNCI: Journal of the National Cancer Institute, 2010, Vol 102, Issue 5, p315
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djq001