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- Title
Free-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking?
- Authors
Zheng, Peixuan; Jeng, Brenda; Huynh, Trinh L. T.; Aguiar, Elroy J.; Motl, Robert W.
- Abstract
Background: Physical function and walking performance have become important outcomes in clinical trials and rehabilitation involving persons with multiple sclerosis (MS). However, assessments conducted in controlled settings may not reflect real-world capacity and movement in a natural environment. Peak cadence via accelerometry might represent a novel measure of walking intensity and prolonged natural effort under free-living conditions. Objective: We compared peak 30-minute cadence, peak 1-minute cadence, and time spent in incremental cadence bands between persons with MS and healthy controls, and examined the associations between peak cadence and laboratory-assessed physical function and walking performance. Methods: Participants (147 MS and 54 healthy controls) completed questionnaires on disability status and self-reported physical activity, underwent the Short Physical Performance Battery, Timed 25-Foot Walk, Timed Up and Go, and 6-Minute Walk, and wore an accelerometer for 7 days. We performed independent samples t -tests and Spearman bivariate and partial correlations adjusting for daily steps. Results: The MS sample demonstrated lower physical function and walking performance scores, daily steps, and peak cadence (P <.001), and spent less time in purposeful steps and slow-to-brisk walking (40-119 steps/minutes), but accumulated more incidental movement (1-19 steps/minutes) than healthy controls. The associations between peak cadence and performance outcomes were strong in MS (| rs | = 0.59-0.68) and remained significant after controlling for daily steps (| prs | = 0.22-0.44), P- values <.01. Peak cadence was inversely correlated with age and disability, regardless of daily steps (P <.01). Conclusions: Our findings provide preliminary evidence for the potential use of peak cadence with step-based metrics for comprehensively evaluating free-living walking performance in MS.
- Subjects
MULTIPLE sclerosis; WALKING speed; STATISTICS; SELF-evaluation; AGE distribution; DISABILITY evaluation; ACCELEROMETERS; PHYSICAL activity; COMPARATIVE studies; T-test (Statistics); WALKING; RESEARCH funding; QUESTIONNAIRES; BODY movement; DATA analysis; DISEASE complications
- Publication
Neurorehabilitation & Neural Repair, 2023, Vol 37, Issue 10, p716
- ISSN
1545-9683
- Publication type
Article
- DOI
10.1177/15459683231206741