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- Title
The role of HPV in the etiopathogenesis of inverted papilloma.
- Authors
Chirilă, Magdalena
- Abstract
Inverted papilloma, first described by Ward in 1854, originates in the sinonasal Schneiderian epithelium, with a ratio of men:women = 3.4:1. In its etiopathogenesis, human papilloma viruses, Epstein-Barr virus or angiogenic factors are incriminated, and there is no unequivocal evidence for any of them. The identification of HPV DNA in both inverted papillomas and those associated with squamous cell carcinomas suggests the role of HPV infection both in their pathogenesis and in the occurrence of malignancy or recurrences, especially in HPV 11/16 and HPV 33/58 coinfections. The most common genetic change in head and neck cancers is the p53 suppressor gene mutation, with a protective effect against the apoptotic response of damaged DNA cells. Viral oncoproteins E6 and E7 are involved in the suppression of p53, with the disruption of cell cycle control. Suppression of p21 (universally present in inverted papilloma lesions) associated with p53 has been identified in all HPV-positive inverted papillomas with severe dysplasia.
- Subjects
PAPILLOMAVIRUSES; PAPILLOMA; SQUAMOUS cell carcinoma
- Publication
ORL.ro, 2021, Issue 50, p30
- ISSN
2067-6530
- Publication type
Article