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- Title
Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment.
- Authors
Fang, Rong; Wang, Gang; Huang, Yue; Zhuang, Jun-Peng; Tang, Hui-Dong; Wang, Ying; Deng, Yu-Lei; Xu, Wei; Chen, Sheng-Di; Ren, Ru-Jing
- Abstract
Background/Aims: As a suitable test to screen for Alzheimer's disease (AD) or mild cognitive impairment (MCI), studies to validate the Chinese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) are rare. Methods: A total of 151 subjects were recruited and the neuropsychological assessments were employed. One-way analysis of variance and Bonferroni correction were used to compare scores of different psychometric scales. Intraclass correlation coefficient (ICC) and Cronbach's coefficient α were used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for mild AD and amnestic subtype of MCI (a-MCI) was assessed by receiver operating characteristic (ROC) curves. Results: The Chinese ACE-R had good reliability (inter-rater ICC = 0.994; test-retest ICC = 0.967) as well as reliable internal consistency (Cronbach's coefficient α = 0.859). With its cutoff of 67/68, the sensitivity (0.920) and specificity (0.857) were lower than for the Mini-Mental State Examination (MMSE) cutoff (sensitivity 1.000 and specificity 0.937) to screen for mild AD. However, the sensitivity of ACE-R to screen for a-MCI was superior to the MMSE with a cutoff of 85/86. The specificity of ACE-R was lower than that of the MMSE to screen for a-MCI. The area under the ROC curve of ACE-R was much larger than that of the MMSE (0.836 and 0.751) for detecting a-MCI rather than mild AD. Conclusion: The Chinese ACE-R is a reliable assessment tool for cognitive impairment. It is more sensitive and accurate in screening for a-MCI rather than for AD compared to the MMSE. © 2013 S. Karger AG, Basel
- Subjects
CHINA; ALZHEIMER'S disease diagnosis; COGNITION disorders diagnosis; MEDICAL screening; ANALYSIS of variance; CHI-squared test; COMPARATIVE studies; STATISTICAL correlation; DIFFERENTIAL diagnosis; NEUROPSYCHOLOGICAL tests; PSYCHOMETRICS; RESEARCH funding; STATISTICS; TRANSLATIONS; DATA analysis; INTER-observer reliability; RECEIVER operating characteristic curves; RESEARCH methodology evaluation; DESCRIPTIVE statistics
- Publication
Dementia & Geriatric Cognitive Disorders, 2014, Vol 37, Issue 3/4, p223
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000353541