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- Title
STUDY OF MUTAGENIC AND ANTITOXIC PROPERTIES OF GENTABIFERON-B.
- Authors
Shabunin, Sergey; Gritsyuk, Vasilina; Vostroilova, Galina; Shabanov, Dmitriy; Khokhlova, Nina; Korchagina, Anastasiya
- Abstract
The combination of immunomodulators and antibiotics in the treatment of animals with diseases of bacterial etiology is one of the effective strategies for animal therapy. The drug gentabiferon-B combines antibiotic gentamicin and speciesspecific (bovine) recombinant interferons -a and -. The study aimed to evaluate the effect of course application of gentabiferon-B on the cytogenetic stability of bone marrow cells of outbred mice after administering mitomycin C (MMC). The proportion of polychromatophilic erythrocytes in the bone marrow was assessed. There was no effect of gentabiferon-B on the frequency of polychromatophilic erythrocytes with micronuclei in both healthy animals and mice with MMC-induced cytogenetic instability. The course application of gentabiferon-B before the administration of MMC led to an increase in the proportion of polychromatophilic erythrocytes (46.03±2.61%) which was non-significantly different than the negative control group. The administration of MMC alone caused a decrease in the proportion of polychromatophilic erythrocytes to 33.33±1.83%. The antitoxic effect of gentabiferon-B led to an increase in the level of polychromatophilic erythrocytes by 38.1% compared to the group that received only MMC. Studies have shown that gentabiferon-B does not have mutagenic activity and anticlastogenic properties, however, it reduces the toxic effect of MMC. In conclusion, it is indicative that gentabiferon-B has antitoxic properties and can be safely used in animal therapy.
- Subjects
ANTIBIOTICS; BONE marrow cells; MUTAGENS; CYTOGENETICS; MITOMYCIN C; BONE marrow; BACTERIAL diseases
- Publication
Macedonian Veterinary Review, 2022, Vol 45, Issue 1, p79
- ISSN
1409-7621
- Publication type
Article
- DOI
10.2478/macvetrev-2022-0016