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- Title
Synthesis of Benzo[c]azepine‐1,3(2H)‐diones via C−H Alkylation/Cyclization with α,β‐Unsaturated Acyl Fluorides.
- Authors
Hosoi, Satoko; Hirata, Yuki; Kurihara, Takumaru; Kojima, Masahiro; Yoshino, Tatsuhiko; Matsunaga, Shigeki
- Abstract
Transition‐metal‐catalyzed directed C−H functionalization reactions are a powerful method to construct N‐heterocycles. However, compared to the formation of five‐ and six‐membered rings, that of seven‐membered rings has been much less explored. Here, the synthesis of benzo[c]azepine‐1,3(2H)‐diones is described, which are benzene‐fused seven‐membered imides, from hydroxamates and α,β‐unsaturated acyl fluorides via C−H activation using a Cp*Rh(III) catalyst. Under mild reaction conditions, this reaction affords benzo[c]azepine‐1,3(2H)‐diones that bear a substituent at the 5‐position.
- Subjects
ALKYLATION; RING formation (Chemistry); IMIDES; CATALYSTS
- Publication
Asian Journal of Organic Chemistry, 2023, Vol 12, Issue 8, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300218