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- Title
Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies.
- Authors
Inho Kim; Sung Soo Yoon; Kyung-Hun Lee; Bhumsuk Keam; Tae Min Kim; Jin-Soo Kim; Hoon-Gu Kim; Myoung-Don Oh; Kyou-Sup Han; Myoung Hee Park; Seonyang Park; Byoung Kook Kim
- Abstract
We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies <50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)-matched donors, via either reduced intensity (n = 35) or myeloablative conditioning (n = 70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p = 0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count >0.5 × 109/L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0–21 d) than in the myeloablative group (median: 18 d; range: 11–38 d; p < 0.0001). The incidence of grades 2–4 acute graft-vs.-host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p = 0.40). The cumulative incidence of day 100 non-relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p = 0.88). The overall two-yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p = 0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies.
- Subjects
HEMATOLOGY; PATIENTS; LEUCOCYTES; ANTIGENS; TRANSPLANTATION of organs, tissues, etc.
- Publication
Clinical Transplantation, 2006, Vol 20, Issue 4, p496
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2006.00512.x