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- Title
Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses.
- Authors
Kurt, Pınar; Emek-Savaç, Derya Durusu; Batum, Kübra; Turp, Bilge; Güntekin, Bahar; Karşıdağ, Sibel; Yener, Görsev Gülmen
- Abstract
Background. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F3, Fz, F4, C3, Cz, C4, P3, Pz, P4, O1, Oz, and O2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2 Hz) were measured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls than MCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F3, Fz, F4, Cz, C4, and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.
- Subjects
MILD cognitive impairment; AUDITORY evoked response; OSCILLATIONS; ALZHEIMER'S patients; AMPLITUDE estimation; ELECTROPHYSIOLOGY; PATIENTS
- Publication
Behavioural Neurology, 2014, p1
- ISSN
0953-4180
- Publication type
Article
- DOI
10.1155/2014/268967