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- Title
Platelet 3H ketanserin binding in migraine.
- Authors
Shukla, R; Khanna, VK; Pradeep, S; Husain, M; Tandon, R; Nag, D; Dikshit, M; Srimal, RC; Seth, PK; Khanna, V K; Srimal, R C; Seth, P K
- Abstract
Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal number of binding sites (Bmax) determined by Scatchard analysis revealed a significant decrease in Kd and no change in Bmax in migraine cases. No correlation was observed between the Kd and Bmax with the clinical features of migraine. The findings of the present study show that there is a decreased affinity of platelet 5-HT2 receptors in migraine.
- Subjects
BLOOD platelets; MIGRAINE; PATHOLOGICAL physiology; CELL receptors; COMPARATIVE studies; DYNAMICS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SEROTONIN; SEROTONIN antagonists; EVALUATION research; BLOOD; CELL physiology
- Publication
Cephalalgia, 2001, Vol 21, Issue 5, p567
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1046/j.1468-2982.2001.00195.x