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- Title
Nitrofurans: Revival of an "old" drug class in the fight against antibiotic resistance.
- Authors
Le, Vuong Van Hung; Rakonjac, Jasna
- Abstract
Current efforts, such as search for improved nitrofuran derivatives, development of new pharmacophores, drug combinations, and repurposed uses of nitrofurans, hold a promise to make this drug class an important weapon in the combat against multidrug-resistant bacterial pathogens in the future. Graph: Fig 1 Mechanism of nitrofuran activation and resistance.(A) Schematic pathway of nitrofuran reduction by NTR enzymes. The identity of enzymes catalyzing the oxygen-sensitive nitrofuran reduction has not been revealed until 2019, when we identified a novel nitrofuran-activating enzyme by selecting for furazolidone-resistant mutants in an I nfsA nfsB E i . I coli i and understanding their biology (physiological functions, regulation of protein expression/action, and enzyme-nitrofuran molecular interaction) would provide useful knowledge to facilitate development of new nitrofuran-based antibacterial therapies.
- Subjects
NITROFURANS; ANTIBIOTICS; DRUG resistance in bacteria; QUORUM sensing; PEROXIREDOXINS; DRUGS; SMALL molecules
- Publication
PLoS Pathogens, 2021, Vol 17, Issue 7, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1009663