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- Title
Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective.
- Authors
Hsu, Alice Jenh; Hanisch, Benjamin R; Fisher, Brian T; Huppler, Anna R
- Abstract
Invasive fungal disease (IFD) remains a significant cause of morbidity and mortality in children undergoing transplantation. There is a growing armamentarium of novel antifungal agents recently approved for use or in late stages of clinical development. The overarching goal of this review is to discuss the mechanisms of action, spectrum of activity, stage of development, and pediatric-specific data for the following agents: encochleated amphotericin B deoxycholate, fosmanogepix, ibrexafungerp, isavuconazole, olorofim, opelconazole, oteseconazole, and rezafungin. Additionally, key drug attributes of these novel agents and their potential future therapeutic roles in pediatric transplant recipients are discussed.
- Subjects
MYCOSES; ANTIFUNGAL agents; PATIENTS; TRANSPLANTATION of organs, tissues, etc.; INVESTIGATIONAL drugs; PEDIATRICS; AMPHOTERICIN B; DRUG development; PHARMACODYNAMICS
- Publication
Journal of the Pediatric Infectious Diseases Society, 2024, Vol 13, pS68
- ISSN
2048-7193
- Publication type
Article
- DOI
10.1093/jpids/piad115