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- Title
The role of insulin-like growth factor-1 in the pathogenesis of cancer and inflammatory skin diseases.
- Authors
Marek-Safiejko, Magda; Myśliwiec, Hanna; Bączyk, Justyna; Flisiak, Iwona
- Abstract
Insulin-like growth factor 1 belongs to the group of polypeptide growth factors. It plays a special role in the regulation of pre- and postnatal growth of the organism, and also has a hypoglycaemic, neuro-, and osteo- and chondroprotective effect. Numerous reports emphasize the role of insulin-like growth factor 1 in the pathogenesis of many cancers, such as breast cancer, prostate cancer, colorectal cancer and lung cancer. Its significant effect in the pathogenesis of some inflammatory skin diseases and in the development of skin cancers, e.g. basal cell carcinoma, squamous cell carcinoma or melanoma has been demonstrated. The article reviews the literature on insulin-like growth factor 1, its receptors and binding proteins, and the role in the pathogenesis of selected skin diseases.
- Subjects
CARCINOGENESIS; SKIN inflammation; SOMATOMEDIN C
- Publication
Dermatology Review / Przeglad Dermatologiczny, 2020, Vol 107, Issue 4, p349
- ISSN
0033-2526
- Publication type
Article
- DOI
10.5114/dr.2020.99879