We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TRAIL-R1 polymorphisms predict the risk of development of hepatocellular carcinoma in Egyptian patients with chronic hepatitis C: a case control study.
- Authors
Osman, Nahla F.; Helwa, Mohamed A.; El Tahawy, Mahmoud A.; Abdelsameea, Eman; Bedir, Hanan
- Abstract
Background Defective apoptosis is a hallmark of cancer development. Tumor necrosis factor-related apoptosis-inducing ligand receptors (TRAIL-R1 or DR4) transmit death signals. Single nucleotide polymorphisms in DR4 gene may lead to defective apoptosis and/or tumor escape. This study aimed to study the relation between DR4-C626G and A683C polymorphisms and the risk for the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV). Patients and methods This prospective randomized controlled study involved 64 HCC-associated HCV (HCC/HCV) patients who were compared with 60 HCV patients with cirrhosis, 60 noncirrhotic HCV patients, 30 patients with HCC secondary to HBV (HCC/HBV) infection, and 100 normal controls. Polymorphisms C626G and A683C of DR4 gene were determined using restriction fragment length polymorphism-PCR. Results The study detected a significant relationship between the presence of C-allele at DR4 C626G and the presence of DR4-683AA genotype as risk factors for the development of HCC in patients with hepatitis C. This relationship was not demonstrated between the HCC/HBV group and controls. Multivariate analysis showed that the combined presence of DR4-683AA genotype, and either DR4-626CG or CC is considered as an independent risk factor with 8.0-fold increased risk for HCC in HCV patients compared with patients carrying other DR4 polymorphisms. Interestingly, the study showed that there was a significant association between those genotypes and high viral load in HCV patients. Conclusion DR4 polymorphisms are associated with the risk of developing HCC in HCV patients and can allow better risk stratification of those patients and can help in the early detection, management, and better outcome of HCC/HCV patients.
- Publication
Egyptian Liver Journal, 2016, Vol 6, Issue 2, p30
- ISSN
2090-6218
- Publication type
Article
- DOI
10.1097/01.ELX.0000514040.77134.c0