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- Title
Cortical plasticity: A proposed mechanism by which genomic factors lead to the behavioral and neurological phenotype of autism spectrum and psychotic-spectrum disorders.
- Authors
Oberman, Lindsay M.; Pascual-Leone, Alvaro
- Abstract
Crespi & Badcock (C&B) hypothesize that biases toward expression of paternally or maternally imprinted genes lead to the symptoms of autism spectrum disorders (ASD) and psychotic-spectrum disorders (PSD), respectively. We suggest that such genetic risk factors may act by inducing abnormalities in developmental and learning-related plasticity. We provide preliminary evidence of abnormal plasticity in ASD and suggest transcranial magnetic stimulation as a useful tool to investigate as well as influence cortical plasticity.
- Subjects
AUTISM; PSYCHOSES; NEUROLOGY; NEUROPLASTICITY; PATHOLOGICAL psychology; PSYCHOLOGY
- Publication
Behavioral & Brain Sciences, 2008, Vol 31, Issue 3, p276
- ISSN
0140-525X
- Publication type
Article
- DOI
10.1017/S0140525X08004378