We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing.
- Authors
Zhou, Yifei; Wang, Xueqing; Song, Mengjiao; He, Zhidong; Cui, Guizhong; Peng, Guangdun; Dieterich, Christoph; Antebi, Adam; Jing, Naihe; Shen, Yidong
- Abstract
Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. Although tissue-specific changes in autophagy and ageing have been extensively explored, the mechanism underlying the inter-tissue regulation of autophagy with ageing is poorly understood. Here, we show that a secreted microRNA, mir-83/miR-29, controls the age-related decrease in macroautophagy across tissues in Caenorhabditis elegans. Upregulated in the intestine by hsf-1/HSF1 with age, mir-83 is transported across tissues potentially via extracellular vesicles and disrupts macroautophagy by suppressing CUP-5/MCOLN, a vital autophagy regulator, autonomously in the intestine as well as non-autonomously in body wall muscle. Mutating mir-83 thereby enhances macroautophagy in different tissues, promoting protein homeostasis and longevity. These findings thus identify a microRNA-based mechanism to coordinate the decreasing macroautophagy in various tissues with age. Decreased autophagy is a hallmark of ageing, but its inter-tissue regulation is poorly understood. Here, Zhou et al. identify mir-83 in C. elegans, which is transported across tissues and suppresses autophagy, contributing to age-related decline.
- Subjects
CAENORHABDITIS elegans; MICRORNA; TISSUES; QUALITY control; LONGEVITY
- Publication
Nature Communications, 2019, Vol 10, Issue 1, pN.PAG
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-019-12821-2