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- Title
Non-Invasive Device-Mediated Drug Delivery to the Brain across the Blood–Brain Barrier.
- Authors
Tashima, Toshihiko; Tournier, Nicolas
- Abstract
This article discusses the challenges of delivering drugs to the brain due to the blood-brain barrier (BBB), which prevents drugs from entering the brain. The article explores various strategies for non-invasive, device-mediated drug delivery across the BBB, including the use of vectors such as monoclonal antibodies, cell-penetrating peptides, and tumor-homing peptides. It also discusses the use of nanodelivery systems utilizing nanoparticles and the potential of nose-to-brain drug delivery. The article highlights the importance of screening methods to analyze drug permeability across the BBB and the transportation of imaging compounds into the brain for neurodegenerative diseases. Overall, the articles in this Special Issue aim to contribute to the development of non-invasive device-mediated brain drug delivery.
- Subjects
BLOOD-brain barrier; ORGANIC cation transporters; P-glycoprotein; COATED vesicles; BIOLOGICAL transport; BLOOD-brain barrier disorders; NANOMEDICINE; DRUG solubility; DRUG delivery devices
- Publication
Pharmaceutics, 2024, Vol 16, Issue 3, p361
- ISSN
1999-4923
- Publication type
Article
- DOI
10.3390/pharmaceutics16030361