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- Title
Multicomponent Reactions for the Synthesis of Active Pharmaceutical Ingredients.
- Authors
Cores, Ángel; Clerigué, José; Orocio-Rodríguez, Emmanuel; Menéndez, J. Carlos
- Abstract
Multicomponent reactions 9i.e., those that engage three or more starting materials to form a product that contains significant fragments of all of them), have been widely employed in the construction of compound libraries, especially in the context of diversity-oriented synthesis. While relatively less exploited, their use in target-oriented synthesis offers significant advantages in terms of synthetic efficiency. This review provides a critical summary of the use of multicomponent reactions for the preparation of active pharmaceutical principles.
- Subjects
CHEMICAL libraries; MANNICH reaction; DRUGS; DIHYDROPYRIDINE; PYRROLES
- Publication
Pharmaceuticals (14248247), 2022, Vol 15, Issue 8, p1009
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph15081009